Additive genetic variation in schizophrenia risk is shared by populations of African and European descent

TR De Candia; SH Lee; J Yang; BL Browning; PV Gejman; DF Levinson; BJ Mowry; JK Hewitt; ME Goddard; MC O'Donovan; SM Purcell; D Posthuma; PM Visscher; NR Wray; MC Keller

Journal article

Additive genetic variation in schizophrenia risk is shared by populations of African and European descent

TR De Candia, SH Lee, J Yang, BL Browning, PV Gejman, DF Levinson, BJ Mowry, JK Hewitt, ME Goddard, MC O'Donovan, SM Purcell, D Posthuma, PM Visscher, NR Wray, MC Keller

American Journal of Human Genetics | Published : 2013

DOI: 10.1016/j.ajhg.2013.07.007

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Abstract

To investigate the extent to which the proportion of schizophrenia's additive genetic variation tagged by SNPs is shared by populations of European and African descent, we analyzed the largest combined African descent (AD [n = 2,142]) and European descent (ED [n = 4,990]) schizophrenia case-control genome-wide association study (GWAS) data set available, the Molecular Genetics of Schizophrenia (MGS) data set. We show how a method that uses genomic similarities at measured SNPs to estimate the additive genetic correlation (SNP correlation [SNP-rg]) between traits can be extended to estimate SNP-rg for the same trait between ethnicities. We estimated SNP-rg for schizophrenia between the MGS ED..

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Mike Goddard Author

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Grants

Awarded by National Institute of Mental Health

Funding Acknowledgements

The authors acknowledge funding from the National Institute of Mental Health (grants K01MH085812 and R01MH100141 to M.C.K., 5T32MH016880-30 to J.K.H., and R01HG004960 and R01HG005701 to B.L.B.), the Australian National Health and Medical Research Council (grants 389892, 442915, 496688, 613672, 613601, 1047956, and 1052684), and the Australian Research Council (grants DP0770096, DP1093502, FT0991360, and DE130100614). The Molecular Genetics of Schizophrenia data set described in this manuscript was obtained from dbGaP, found at http://www.ncbi.nlm.nih.gov/gap, through study accession numbers phs000021.v3.p2 and phs000167.v1.p1. This manuscript does not necessarily reflect the opinions or views of the funding agencies or institutes who helped in collection of this data. Acknowledgments for the International Schizophrenia Consortium and the Molecular Genetics of Schizophrenia Collaboration can be found in the Supplemental Data.